The current COVID-19 pandemic is motivating us to elucidate the molecular mechanism denver broncos airpods case of SARS-CoV-2 invasion and find methods for decreasing its transmissibility.We found that SARS-CoV-2 could increase the protein level of ACE2 in mice.Folic acid and 5-10-methylenetetrahydrofolate reductase (MTHFR) could promote the methylation of the ACE2 promoter and inhibit ACE2 expression.
Folic acid treatment decreased the binding ability of Spike protein, pseudovirus and inactivated authentic SARS-CoV-2 to host cells.Thus, folic acid treatment could sara stedy stand aid decrease SARS-CoV-2 invasion and SARS-CoV-2-neutralizing antibody production in mice.These data suggest that increased intake of folic acid may inhibit ACE2 expression and reduce the transmissibility of SARS-CoV-2.
Folic acid could play an important role in SARS-CoV-2 infection prevention and control.